His second and third albums, 2000 Watts and I Wanna Go There, were released in 2001 and 2002, respectively. The latter contained the lead single “How You Gonna Act Like That”, which became Gibson’s highest-charting single, reaching number seven on the Billboard Hot 100.

His fourth album, Alter Ego, explored hip hop, while he was nominated for the Grammy Award for Best R&B Album for his fifth album, Open Invitation (2011). Gibson’s sixth album, Black Rose (2015), debuted at number one on the U.S. Billboard 200, becoming his highest-charting album. He has sold over 4 million records in the United States.

Gibson had his first starring role in John Singleton’s coming-of-age hood film Baby Boy (2001), and gained widespread recognition as Roman Pearce in the Fast & Furious franchise. Gibson reunited with Singleton for the action film Four Brothers (2005) and plays Robert Epps in the Transformers franchise. He appeared in the comedy film Ride Along 2 (2016) and appeared in the superhero film Morbius (2022).